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    題名: Multispectra CWT-based Algorithm(MCWT) in Mass Spectra for Peak Extraction
    作者: 薛慧敏;郭訓志;蔡政安
    Hsueh, Huey-Miin;Kuo, Hsun-chih;Tsai, Chen-An
    貢獻者: 統計系
    日期: 2008-09
    上傳時間: 2014-12-16 10:38:50 (UTC+8)
    摘要: An important objective in mass spectrometry (MS) is to identify a set of biomarkers that can be used to potentially distinguish patients between distinct treatments (or conditions) from tens or hundreds of spectra. A common two-step approach involving peak extraction and quantification is employed to identify the features of scientific interest. The selected features are then used for further investigation to understand underlying biological mechanism of individual protein or for development of genomic biomarkers to early diagnosis. However, the use of inadequate or ineffective peak detection and peak alignment algorithms in peak extraction step may lead to a high rate of false positives. Also, it is crucial to reduce the false positive rate in detecting biomarkers from ten or hundreds of spectra. Here a new procedure is introduced for feature extraction in mass spectrometry data that extends the continuous wavelet transform-based (CWT-based) algorithm to multiple spectra. The proposed multispectra CWT-based algorithm (MCWT) not only can perform peak detection for multiple spectra but also carry out peak alignment at the same time. The author' MCWT algorithm constructs a reference, which integrates information of multiple raw spectra, for feature extraction. The algorithm is applied to a SELDI-TOF mass spectra data set provided by CAMDA 2006 with known polypeptide m/z positions. This new approach is easy to implement and it outperforms the existing peak extraction method from the Bioconductor PROcess package.
    關聯: Journal of Biopharmaceutical Statistics,18(5),869-882
    資料類型: article
    DOI 連結: http://dx.doi.org/10.1080/10543400802278064
    DOI: 10.1080/10543400802278064
    顯示於類別:[統計學系] 期刊論文

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