![](/image/logo.gif) |
English
|
正體中文
|
简体中文
|
Post-Print筆數 : 27 |
全文筆數/總筆數 : 111316/142225 (78%)
造訪人次 : 48397775
線上人數 : 676
|
|
|
資料載入中.....
|
請使用永久網址來引用或連結此文件:
https://nccur.lib.nccu.edu.tw/handle/140.119/74028
|
題名: | Gestational exposure to polychlorinated biphenyls and dibenzofurans induced asymmetric hearing loss: Yucheng children study |
作者: | Li, Mingchieh;Wu, H.-P.;Yang, C.-Y.;Chen, P.-C.;Lambert, G.H.;Leon, Guo Y. 李銘杰 |
貢獻者: | 法科所 |
關鍵詞: | Polychlorinated dibenzofurans;Polychlorinated biphenyls;PCDFs;PCBs;Yucheng;Hearing loss;Prenatal;Gestational |
日期: | 2015-02 |
上傳時間: | 2015-03-25 10:15:56 (UTC+8) |
摘要: | Abstract
Introduction
In 1979, approximately 2000 people in central Taiwan were exposed to polychlorinated biphenyls and dibenzofurans (PCBs/PCDFs) due to ingestion of contaminated rice oil. The children born to mothers exposed to PCBs/PCDFs were called Yucheng children. We conducted a follow-up study to examine the association between gestational PCBs/PCDFS exposure and auditory function in Yucheng children`s early adulthood.
Methods
In 1985 and early 1992, Yucheng children and their age, gender, socio-economic matched unexposed referent children were recruited for physical examination and long-term follow-ups. In 2007, Yucheng children and referent children were invited to participate in a health examination, including assessment of pure-tone air-conduction thresholds and distortion product otoacoustic emissions (DPOAEs) test. Gestational exposure to PCBs/PCDFs in Yucheng children were estimated by back-extrapolation of their mother`s serum concentration to the time of childbirth.
Results
A total of 86 Yucheng children (51.2% males) and 97 referent children (50.5% males) were included for analysis. No difference was found in demographic characteristics between two groups. Among the Yucheng children, 53 had estimated PCBs/PCDFs concentrations. We found that Yucheng children were at higher risk of having elevated hearing threshold at low frequencies in the right ear. Estimated maternal concentrations of 2,3,4,7,8-pnCDF at the time of birth were associated with increased hearing thresholds and decreased DPOAEs amplitudes at low frequencies in the right ear.
Conclusion
Gestational exposure to PCBs/PCDFs caused adverse asymmetrical hearing effects detectable even in early adulthood. |
關聯: | Environmental Research,137,65-71 |
資料類型: | article |
DOI 連結: | http://dx.doi.org/10.1016/j.envres.2014.12.002 |
DOI: | 10.1016/j.envres.2014.12.002 |
顯示於類別: | [法律科際整合研究所] 期刊論文
|
文件中的檔案:
檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
j.envres.2014.12.002.pdf | | 331Kb | Adobe PDF2 | 1290 | 檢視/開啟 |
|
在政大典藏中所有的資料項目都受到原著作權保護.
|
著作權政策宣告 Copyright Announcement1.本網站之數位內容為國立政治大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,惟仍請適度,合理使用本網站之內容,以尊重著作權人之權益。商業上之利用,則請先取得著作權人之授權。
The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.
2.本網站之製作,已盡力防止侵害著作權人之權益,如仍發現本網站之數位內容有侵害著作權人權益情事者,請權利人通知本網站維護人員(
nccur@nccu.edu.tw),維護人員將立即採取移除該數位著作等補救措施。
NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(
nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.