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    题名: The relationship between serum uric acid concentration and metabolic syndrome in patients with schizophrenia or schizoaffective disorder
    作者: Chiu, C.-C.;Chen, C.-H.;Tsai, Chang-Jer
    蔡長哲
    贡献者: 神經科研所
    关键词: antidiabetic agent;antihypertensive agent;clozapine;high density lipoprotein cholesterol;olanzapine;uric acid;adult;anthropometry;antihypertensive therapy;article;chemical analysis;cholesterol blood level;cross-sectional study;female;human;hyperglycemia;hypertension;hypertriglyceridemia;major clinical study;male;metabolic syndrome X;priority journal;schizoaffective psychosis;sex difference;uric acid blood level;Adult;Cholesterol, HDL;Cross-Sectional Studies;Female;Humans;Hypertension;Hypertriglyceridemia;Male;Metabolic Syndrome X;Middle Aged;Psychotic Disorders;Risk;Schizophrenia;Sex Factors;Uric Acid
    日期: 2012-10
    上传时间: 2015-05-12 16:20:28 (UTC+8)
    摘要: Higher prevalence rates of metabolic syndrome (MetS) in patients with schizophrenia are getting more and more attention. Uric acid (UA) has been frequently reported to be associated with MetS in the general population. Sex difference in this relationship is inconsistent. As a selective antioxidant, UA has also been found to be reduced in patients with schizophrenia, and this effect may be prominent in men. With the inconsistent presentations, higher rate of MetS but possible lower UA concentrations, the aim of this study was to investigate the relationship by sexes between serum UA concentrations and prevalence of MetS in patients with schizophrenia or schizoaffective disorder. A total of 637 patients, 342 male and 295 female, were enrolled from 36 psychiatric rehabilitation institutions. Cross-sectional anthropometrical data, biochemical analysis, and serum UA were measured. Serum UA concentrations were divided into quartiles by sexes. Modified National Cholesterol Education Program Adult Treatment Panel III criteria for Asians were used as diagnosis of MetS. After adjustment, higher UA concentrations are associated with hypertriglyceridemia, low high-density lipoprotein cholesterol level, and high blood pressure in men and with hypertriglyceridemia in women. Significantly higher odds ratios for MetS in the UA third (4.02; 95% confidence interval, 1.33-12.1) and fourth quartiles (9.28; 95% confidence interval, 2.90-29.8) compared with the lowest quartile were found in men but not in women after adjustment. These results suggest that lower UA concentrations in male patients with schizophrenia or schizoaffective disorder are associated with lower risk of MetS. © 2012 Lippincott Williams & Wilkins.
    關聯: Journal of Clinical Psychopharmacology, Volume 32, Issue 5, 2012, Pages 585-592
    数据类型: article
    DOI 連結: http://dx.doi.org/10.1097/JCP.0b013e3182664e64
    DOI: 10.1097/JCP.0b013e3182664e64
    显示于类别:[神經科學研究所] 期刊論文

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