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    题名: Oxidative stress status in recently abstinent methamphetamine abusers
    作者: Huang, M.-C.;Lin, S.-K.;Chen, Chen C.-H.;Pan, Chun-Hung;Lee, C.-H.;Liu, H.-C.
    潘俊宏
    贡献者: 心理系
    关键词: catalase;glutathione;malonaldehyde;methamphetamine;superoxide dismutase;adult;article;comparative study;controlled study;drug abuse;drug withdrawal;enzyme blood level;female;human;major clinical study;male;oxidative stress;smoking;urinalysis;Adult;Amphetamine-Related Disorders;Antioxidants;Case-Control Studies;Catalase;Female;Glutathione;Humans;Male;Malondialdehyde;Methamphetamine;Oxidative Stress;Superoxide Dismutase
    日期: 2013-02
    上传时间: 2015-05-21 16:33:31 (UTC+8)
    摘要: Aim Methamphetamine (METH) administration is associated with excessive oxidative stress. It is not known whether the systemic oxidative stress indices would alter during early abstinence in METH abusers with positive urine testing for recent METH exposure. Methods Sixty-four non-treatment-seeking METH abusers enrolled from a controlled environment and 60 healthy controls participated in the study. Fasting serum malondialdehyde (MDA) levels and anti-oxidant indices, including superoxide dismutase (SOD) and catalase (CAT) activity, and glutathione (GSH) levels, were measured at baseline and 2 weeks after the first measurement. We compared the differences of these oxidative stress indices between METH abusers and controls and examined the changes of the indices 2 weeks after baseline in the METH group. Results At baseline, the recently abstinent METH abusers had significantly higher MDA levels, lower SOD activity, and higher CAT activity and GSH levels compared to healthy controls. CAT and GSH values were positively correlated with MDA but negatively correlated with SOD. These oxidative stress indices did not significantly correlate with age, smoking amount, Alcohol Use Disorder Identification Test scores, or METH use variables. After 2 more weeks of abstinence, the indices did not alter nor normalize. Conclusion Compared to controls, we found that METH abusers have persistently higher systemic oxidative stress throughout early abstinence. The compromised SOD as well as elevated CAT activity and GSH levels may act together as a compensatory mechanism to counteract excessive oxidative stress induced by METH. Whether the oxidative stress could improve after a longer period of abstinence needs to be examined in future studies. © 2013 The Authors. Psychiatry and Clinical Neurosciences © 2013 Japanese Society of Psychiatry and Neurology.
    關聯: Psychiatry and Clinical Neurosciences, 67(2), 92-100
    数据类型: article
    DOI 連結: http://dx.doi.org/10.1111/pcn.12025
    DOI: 10.1111/pcn.12025
    显示于类别:[心理學系] 期刊論文

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