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    题名: The anti-aging effects of Ludwigia octovalvis on Drosophila melanogaster and SAMP8 mice
    作者: Lin, W.-S.;Chen, Junyi;Wang, J.-C.
    贡献者: 神科所
    关键词: 1;1 diphenyl 2 picrylhydrazyl;2 n butyldecalin;ascorbic acid;beta sitosterol ether;campesterol;chemical compound;dehydrodesoxyindolin codeine;deoxyglucose;distearyl phosphate;ethyl hexadecanoic acid ester;ethyl linoleic acid ester;flavonoid;hydroxymethylglutaryl coenzyme A reductase kinase;ludwigia octovalvis extract;methyl octadecyne;mifepristone;neophytadiene;paraquat;phytol;plant extract;polyphenol;resveratrol;sitosterol;spiro acid;squalene;stigmastan triene;stigmasterol;trihydroxy isopropyl methoxy anthraquinone;trimethyl pentadecanone;unclassified drug;unindexed drug;aging;animal cell;animal experiment;animal tissue;anti aging effect;article;cognitive defect;controlled study;diet restriction;DPPH radical scavenging assay;Drosophila melanogaster;drug activity;enzyme activation;fat body;female;fertility;fluid intake;food intake;lethality;lifespan;low calory diet;Ludwigia octovalvis;male;mass fragmentography;motor activity;nonhuman;Onagraceae;oxidative stress;senescence accelerated mouse;Aging;AMP-Activated Protein Kinases;Animals;Blotting;Western;Caloric Restriction;Cells;Cultured;Drosophila melanogaster;Enzyme Activation;Gas Chromatography-Mass Spectrometry;Gene Expression Regulation;Developmental;Longevity;Male;Mice;Mice;Inbred Strains;Onagraceae;Oxidative Stress;Phytotherapy;Plant Preparations;Real-Time Polymerase Chain Reaction;RNA
    日期: 2014-04
    上传时间: 2015-06-02 17:25:17 (UTC+8)
    摘要: We investigated the anti-aging effects of Ludwigia octovalvis (Jacq.) P. H. Raven (Onagraceae), an extract of which is widely consumed as a healthful drink in a number of countries. Using the fruit fly, Drosophila melanogaster, as a model organism, we demonstrated that L. octovalvis extract (LOE) significantly extended fly lifespan on a high, but not a low, calorie diet, indicating that LOE may regulate lifespan through a dietary restriction (DR)-related pathway. LOE also attenuated age-related cognitive decline in both flies and in the senescence-accelerated-prone 8 (SAMP8) mouse, without causing any discernable negative trade-offs, including water intake, food intake, fecundity, or spontaneous motor activity. LOE contained high levels of polyphenols and flavonoids, which possess strong DPPH radical scavenging activity, and was shown to attenuate paraquat-induced oxidative damage and lethality in flies. Gas chromatography-mass spectrometry (GC-MS) analyses identified 17 known molecules, of which β-sitosterol and squalene were the two most abundant. We further demonstrated that β-sitosterol was capable of extending lifespan, likely through activating AMP-activated protein kinase (AMPK) in the fat body of adult flies. Taken together, our data suggest that LOE is a potent anti-aging intervention with potential for treating age-related disorders. © 2013 American Aging Association.
    關聯: Age, 36(2), 689-703
    数据类型: article
    DOI 連結: http://dx.doi.org/10.1007/s11357-013-9606-z
    DOI: 10.1007/s11357-013-9606-z
    显示于类别:[神經科學研究所] 期刊論文

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