English  |  正體中文  |  简体中文  |  Post-Print筆數 : 27 |  Items with full text/Total items : 109948/140897 (78%)
Visitors : 46078034      Online Users : 940
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version
    政大機構典藏 > 理學院 > 心理學系 > 期刊論文 >  Item 140.119/75661


    Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/75661


    Title: Lack of efficacy of dextromethorphan in managing alcohol withdrawal: A preliminary report of a randomized, double-blind, placebo-controlled trial
    Authors: Huang, M.-C.;Chen, C.-H.;Pan, Chun-Hung;Lin, S.-K.
    潘俊宏
    Contributors: 心理系
    Keywords: alcohol;dextromethorphan;lorazepam;multivitamin;placebo;thiamine;adult;alcohol consumption;alcohol withdrawal;alcoholism;article;clinical assessment;Clinical Institute Withdrawal Assessment for Alcohol;controlled study;detoxification;dizziness;double blind procedure;drinking behavior;drug efficacy;drug megadose;drug safety;fatigue;hospital admission;human;neurological complication;Obsessive Compulsive Drinking Scale;outcome assessment;priority journal;psychometry;randomized controlled trial;rating scale;scoring system;somnolence;symptom;treatment duration;treatment outcome;Adult;Alcohol Abstinence;Alcohol Drinking;Alcoholism;Brain;Dextromethorphan;Double-Blind Method;Drug Therapy;Combination;Excitatory Amino Acid Antagonists;Humans;Lorazepam;Middle Aged;Psychiatric Status Rating Scales;Receptors;N-Methyl-D-Aspartate;Substance Withdrawal Syndrome;Taiwan;Time Factors;Treatment Failure
    Date: 2014-02
    Issue Date: 2015-06-11 12:05:02 (UTC+8)
    Abstract: Alcohol withdrawal syndrome is associated with increased central N-methyl-D-aspartate (NMDA) glutamate transmission. Medications that reduce glutamate release or block NMDA overactivation have shown efficacy for treating alcohol withdrawal syndrome. Dextromethorphan (DXM), a widely used antitussive drug, is a low-affinity, noncompetitive NMDA antagonist with potential neuroprotective properties. This study, using a randomized, double-blind, placebo-controlled study design, examined the benefit of DXM in the management of acute alcohol withdrawal. Alcohol-dependent patients admitted for detoxification treatment and experiencing moderate alcohol withdrawal, as measured by a score greater than 10 on the revised Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar), were randomly assigned to receive either DXM 360 mg/d or an identical placebo for 7 days in a double-blind manner. All subjects received a concurrent dose of lorazepam 2 mg along with the initial administration of DXM or placebo and were given additional lorazepam (1 mg) as a rescue medication according to the symptom-triggered detoxification protocol. Outcome measures consisted of the mean total dose of lorazepam received, the sequential scores on the CIWA-Ar, and craving assessed by the Obsessive-Compulsive Drinking Scale. Forty subjects completed the study, 18 in the DXM group and 22 in the placebo group. We found that compared with placebo, DXM use was not associated with lower lorazepam doses to control alcohol withdrawal symptoms. The progression in CIWA-Ar and Obsessive-Compulsive Drinking Scale scores was also comparable between the 2 groups. Our preliminary results do not support the efficacy of high-dose DXM in reducing the need of benzodiazepines to treat withdrawal symptoms in alcohol-dependent patients. © 2014 Lippincott Williams & Wilkins.
    Relation: Journal of Clinical Psychopharmacology, 34(1), 149-152
    Data Type: article
    DOI 連結: http://dx.doi.org/10.1097/JCP.0000000000000052
    DOI: 10.1097/JCP.0000000000000052
    Appears in Collections:[心理學系] 期刊論文

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML21365View/Open


    All items in 政大典藏 are protected by copyright, with all rights reserved.


    社群 sharing

    著作權政策宣告 Copyright Announcement
    1.本網站之數位內容為國立政治大學所收錄之機構典藏，無償提供學術研究與公眾教育等公益性使用，惟仍請適度，合理使用本網站之內容，以尊重著作權人之權益。商業上之利用，則請先取得著作權人之授權。
    The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.

    2.本網站之製作，已盡力防止侵害著作權人之權益，如仍發現本網站之數位內容有侵害著作權人權益情事者，請權利人通知本網站維護人員(nccur@nccu.edu.tw)，維護人員將立即採取移除該數位著作等補救措施。
    NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback