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政大機構典藏 > 理學院 > 心理學系 > 期刊論文 > Item 140.119/77934

Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/77934

Title:	Antinociceptive Effects of Nociceptin/Orphanin FQ Administered Intrathecally in Monkeys
Authors:	Ko, Mei-Chuan 柯美全 Naughton, Norah N.
Contributors:	心理系
Keywords:	Spinal cord;analgesia;NOP receptors;substance P;thermal hyperalgesia
Date:	2009-05
Issue Date:	2015-08-24 10:54:50 (UTC+8)
Abstract:	Nociceptin/orphanin FQ (N/OFQ) is the endogenous peptide for the NOP receptors. Depending on the doses, intrathecal administration of N/OFQ has dual actions (ie, hyperalgesia and antinociception) in rodents. However, the pharmacological profile of intrathecal N/OFQ is not fully known in primates. The aim of this study was to investigate behavioral effects of intrathecal N/OFQ over a wide dose range and to compare its effects with ligands known to produce hyperalgesia or antinociception in monkeys. Intrathecal N/OFQ from 1 fmol to 1 nmol did not produce any hyperalgesic or scratching responses. In contrast, intrathecal substance P 100 nmol produced hyperalgesia, and intrathecal DAMGO 10 nmol produced antinociception. At the dose range between 10 nmol and 1 μmol, intrathecal N/OFQ dose-dependently produced thermal antinociception against a noxious stimulus in 2 intensities. More importantly, N/OFQ in combined with intrathecal morphine dose-dependently potentiated morphine-induced antinociception without inhibiting morphine-induced itch/scratching. Taken together, this study is the first to provide a unique functional profile of intrathecal N/OFQ over a wide dose range in primates. Intrathecal N/OFQ produces thermal antinociception without anti-morphine actions or scratching responses, indicating that N/OFQ or NOP receptor agonists represent a promising target as spinal analgesics.
Relation:	The Journal of Pain, 10(5), 509-516
Data Type:	article
DOI 連結:	http://dx.doi.org/10.1016/j.jpain.2008.11.006
DOI:	10.1016/j.jpain.2008.11.006
Appears in Collections:	[心理學系] 期刊論文

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