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政大典藏 > College of Commerce > Department of Statistics > Periodical Articles > Item 140.119/79419

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Title:	Reduced Gut Acidity Induces an Obese-Like Phenotype in Drosophila melanogaster and in Mice
Authors:	Lin, Wei-Sheng;Huang, Cheng-Wen;Song, You-Sheng;Yen, Jui-Hung;Kuo, Ping-Chang;Yeh, Sheng-Rong;Lin, Hung-Yu;Fu, Tsai-Feng;Wu, Ming-Shiang;Wang, Horng-Dar;Wang, Pei-Yu 江振東
Contributors:	統計系
Date:	2015-10
Issue Date:	2015-11-25 16:35:57 (UTC+8)
Abstract:	In order to identify genes involved in stress and metabolic regulation, we carried out a Drosophila P-element-mediated mutagenesis screen for starvation resistance. We isolated a mutant, m2, that showed a 23% increase in survival time under starvation conditions. The P-element insertion was mapped to the region upstream of the vha16-1 gene, which encodes the c subunit of the vacuolar-type H+-ATPase. We found that vha16-1 is highly expressed in the fly midgut, and that m2 mutant flies are hypomorphic for vha16-1 and also exhibit reduced midgut acidity. This deficit is likely to induce altered metabolism and contribute to accelerated aging, since vha16-1 mutant flies are short-lived and display increases in body weight and lipid accumulation. Similar phenotypes were also induced by pharmacological treatment, through feeding normal flies and mice with a carbonic anhydrase inhibitor (acetazolamide) or proton pump inhibitor (PPI, lansoprazole) to suppress gut acid production. Our study may thus provide a useful model for investigating chronic acid suppression in patients.
Relation:	PLoS One, 10(10), e0139722
Data Type:	article
DOI link:	http://dx.doi.org/10.1371/journal.pone.0139722
DOI:	10.1371/journal.pone.0139722
Appears in Collections:	[Department of Statistics] Periodical Articles

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