政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/80587

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政大機構典藏 > 理學院 > 應用物理研究所 > 期刊論文 > Item 140.119/80587

Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/80587

Title:	Three arginine-rich cell-penetrating peptides facilitate cellular internalization of red-emitting quantum dots
Authors:	Liu, B.R.;Chen, H.H.;Chan, M.H.;Huang, Y.W.;Aronstam, R.S;Lee, H.J.*
Contributors:	神科所
Date:	2015
Issue Date:	2016-01-14 17:57:16 (UTC+8)
Abstract:	Nanoparticles, such as semiconductor quantum dots (QDs), have been found increasing use in biomedical diagnosis and therapeutics because of their unique properties, including quantum confinement, surface plasmon resonance, and superparamagnetism. Cell-penetrating peptides (CPPs) represent an efficient mechanism to overcome plasma membrane barriers and deliver biologically active molecules into cells. In this study, we demonstrate that three arginine-rich CPPs (SR9, HR9, and PR9) can noncovalently complex with red light emitting QDs, dramatically increasing their delivery into living cells. Zeta-potential and size analyses highlight the importance of electrostatic interactions between positive-charged CPP/QD complexes and negative-charged plasma membranes indicating the efficiency of transmembrane complex transport. Subcellular colocalization indicates associations of QD with early endosomes and lysosomes following PR9-mediated delivery. Our study demonstrates that nontoxic CPPs of varied composition provide an effective vehicle for the design of optimized drug delivery systems.
Relation:	Journal of Nanoscience and Nanotechnology, 15, 2067-2078.
Data Type:	article
DOI 連結:	http://dx.doi.org/10.1166/jnn.2015.9148
DOI:	10.1166/jnn.2015.9148
Appears in Collections:	[應用物理研究所 ] 期刊論文

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