政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/86501

English | 正體中文 | 简体中文 | Post-Print筆數 : 27 | 全文笔数/总笔数 : 110944/141864 (78%)
造访人次 : 47867285 在线人数 : 1106

RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.

政大機構典藏 > 商學院 > 統計學系 > 學位論文 > Item 140.119/86501

请使用永久网址来引用或连结此文件: https://nccur.lib.nccu.edu.tw/handle/140.119/86501

题名:	在不同實驗設計下藥物個體生體相等性檢定力之比較
作者:	董雅萍
贡献者:	江振東董雅萍
关键词:	生體可用相對值平均生體相等性個體生體相等性檢定力交叉實驗設計樣本數 Average bioequivalence Individual bioequivalence Power Coverage probability
日期:	1997
上传时间:	2016-04-27 11:24:15 (UTC+8)
摘要:	傳統上，判定一種學名藥(generic drug)與原廠藥(innovator drug)是否具有生體相等性所常用的統計方法為：比較兩種藥物的生體可用相對值(relative bioavailability)的母體平均數是否相等，此即所謂的平均生體相等性(average bioequivalence)。然而就兩種藥物可互用的觀點而言，似乎更需要考慮的是每位受測個體在服用藥物後，不同藥物在個體內反應的差異性，因此 Anderson and Hauck (1990)提出個體生體相等性(individual bioequivalence)的觀點。 Conventionally, that a generic drug and an innovator drug are regarded as having the same treatment effects is based on the concept of average bioequivalence,i.e., that average responses between individuals on the two formulations are similar. Anderson and Hauck (1990) argued that it was not sufficient to expect that an individual patient would response similarly to the two formulations. The thought has received a lot of attention lately, and quite a few methods have been proposed to deal with the issue of the individual bioequivalence. According to the "unified" approach proposes by Schall (1995), a simulation study on power to declare bioequivalence and coverage probability of confidence intervals is carried out here to compare their performance under different experimental designs.
描述:	碩士國立政治大學統計學系 85354012
資料來源:	http://thesis.lib.nccu.edu.tw/record/#B2002002096
数据类型:	thesis
显示于类别:	[統計學系] 學位論文

文件中的档案:

没有与此文件相关的档案.

在政大典藏中所有的数据项都受到原著作权保护.

社群 sharing

著作權政策宣告 Copyright Announcement

1.本網站之數位內容為國立政治大學所收錄之機構典藏，無償提供學術研究與公眾教育等公益性使用，惟仍請適度，合理使用本網站之內容，以尊重著作權人之權益。商業上之利用，則請先取得著作權人之授權。
The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.

2.本網站之製作，已盡力防止侵害著作權人之權益，如仍發現本網站之數位內容有侵害著作權人權益情事者，請權利人通知本網站維護人員(nccur@nccu.edu.tw)，維護人員將立即採取移除該數位著作等補救措施。
NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.

数据加载中.....