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    题名: 功能性磁共振頻譜在3T系統下的可行性:以視覺實驗驗證
    Feasibility of functional MRS in 3T system:demonstration using visual experiments
    作者: 蔡育儒
    Tsai, Yu Ju
    贡献者: 蔡尚岳
    Tsai, Shang Yueh
    蔡育儒
    Tsai, Yu Ju
    关键词: 功能性慈振頻譜
    相位循環
    視覺刺激
    functional MR spectroscopy
    Phase cycling
    visual stimulation
    日期: 2016
    上传时间: 2016-05-02 13:56:00 (UTC+8)
    摘要: 核磁共振頻譜技術提供了非侵入式方法檢測大腦代謝物濃度的變化，功能性磁振頻譜(functional Magnetic Resonance Spectroscopy，fMRS)為在接受外在刺激下大腦活動時所量測的頻譜訊號(非一般的影像)。此研究在約21分鐘的視覺刺激模式下進行，代謝物量測的時間序列頻譜由LCModel(Linear Combination of Model)計算出每張掃描的濃度、擬合(fitting)及CRLB(Cramér–Rao lower bound)。

    近年來，有文獻指出在7T的磁場下利用功能性磁振頻譜技術在腦部視覺皮質區(Visual cortex)在接收視覺刺激下，代謝物濃度有改變的現象，其中包含谷氨酸(Glutamate)、乳酸(Lactate)的濃度在視覺刺激當下會有所增加；葡萄糖(Glucose)有減少的傾向但不明顯。

    本研究的目的為在3T的磁場下，當受試者在接受視覺刺激時，探討大腦在視覺區的代謝物濃度變化，並比較有使用相位循環(Phase Cycling, PC)與無相位循環(NO_Phase Cycling, NO_PC)兩種結果有哪些差異。其後我們發現在幾次的實驗裡部分代謝物間出現濃度在某時刻下有相同的跳躍或相同趨勢的現象，尤其是在無相位循環的時候，該現象也比較常出現，為此我們也做了代謝物濃度的相關係數分析，計算不同的代謝物之間的關聯性以及平均結果。
    Functional magnetic resonance spectroscopy (fMRS) provides a non-invasive technique to investigate brain metabolism during brain activation. Concentration, fitting and CRLB of the measurements were evaluated from LCModel analysis of time series of spectra measured during 21 mins visual stimulation paradigm

    Recently, several researches indicated that using functional magnetic resonance spectroscopy at 7T magnetic field brain metabolism concentration in visual cortex will change during visual stimulation. Glutamate(Glu), Lactate(Lac) increased during periods of stimulation; Glucose (Glc) showed a tendency to decrease, but not significantly.

    The purpose of this study is to investigate metabolism concentration changes at 3T field in MRS during visual stimulation, and compare what kind of difference of phase cycling and not-phase cycling. Then we found a few experiments in concentration between parts of metabolites appear to have the same or the same tendency to jump at a certain time of the phenomenon, especially no_phase cycling.We also calculated correlation coefficient of metabolite and the result of average.
    參考文獻: [1] Robin A. de Graaf. In vivo NMR Spectroscopy principles and techniques2nd:Wiley-Interscience,2008

    [2] S.Ogawa, T.M.Lee,A.R.Kay and D.W.Tank. (1990). Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Biophysics l8:9868-9872.

    [3] James Prichard, Douglas Rothman, Edward Novotny, Ognen Petroff, Takeo Kuwabara, Malcolm Avison, Alistair Howseman, Christopher Hanstock, and Robert Shulman. (1991). Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation. Medical Science 88: 5829-5831

    [4] S.Mangia, G.Garreffa, M.Bianciardi, F.Giove, F.Di Salle and B.Maraviglia. (2003). The aerobic brain actate decrease at the onset of neural activity. Neuralscience 118:7-10

    [5] Xiao-Hong Zhu and Wei Chen. (2001). Observed BOLD Effects on Cerebral Metabolite Resonances in Human Visual Cortex During Visual Stimulation: A Functional 1H MRS Study at 4 T. Magn Reson Med 46:841-847

    [6] Paola Sarchielli, Roberto Tarducci, Otello Presciutti, Gianni Gobbi, Gian Piero Pelliccioli, Giuseppe Stipa, Andrea Alberti, and Giuseppe Capocchi. (2005). Functional 1H-MRS findings in migraine patients with and without aura assessed interictally. Neuroimage 24:1025-1031.


    [7] Silvia Mangia, Ivan Tkáč, Rolf Gruetter, Pierre-Francois Van de Moortele, Bruno Maraviglia and Kâmil Uğurbil. (2007). Sustained neuronal activation raises oxidative metabolism to a new steady-state level:evidence from H NMR spectroscopy in the human visual cortex. J Cereb Blood Flow Metab 27:1055-1063

    [8] Yan Lin, Mary C Stephenson, Lijing Xin, Antonio Napolitano and PG Morris. (2012).
    Investigating the metabolic changes due to visual stimulation using functional proton magnetic resonance spectro-scopy at 7T. J Cereb Blood Flow Metab 32:1484-1495

    [9] Benoît Schaller, Lijing Xin, Kieran O’Brien, Arthur W.Magill, Rolf Gruetter. (2014). Are glutamate and lactate increases ubiquitous to physiological activation?A 1H functional MR spectroscopy study during motor activation in human brain at 7 Tesla. Neuroimage 93:138-145.

    [10] Wulf-Ingo Jung, Localized double spin echo proton spectroscopy part I:basic concepts.

    [11] G.Castellano, C.S.B.Dias, B.Foerster, L.M.Li and R.J.M Covolan. (2012). NAA and NAAG variation in neuronal activation during visual stimulation. Braz J Med Bio Res 45(11):1031-1036
    描述: 碩士
    國立政治大學
    應用物理研究所
    102755009
    資料來源: http://thesis.lib.nccu.edu.tw/record/#G1027550091
    数据类型: thesis
    显示于类别:[應用物理研究所 ] 學位論文

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