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    题名: Differential inhibitory effects of resveratrol on excitotoxicity and synaptic plasticity: involvement of NMDA receptor subtypes
    作者: 詹銘煥
    Chan, Ming-Huan
    Hsieh, Chung-Pin
    Chang, Wei-Tang
    Chen, Linyi
    Chen, Hwei-Hsien
    贡献者: 神科所
    日期: 2021-07
    上传时间: 2021-10-27 10:57:07 (UTC+8)
    摘要: Objectives: The neuroprotective effects of resveratrol against excitatory neurotoxicity have been associated with N-methyl-D-aspartate receptor (NMDAR) inhibition. This study examined the differential inhibitory effects of resveratrol on NMDAR-mediated responses in neuronal cells with different NMDAR subtype composition. Methods: The effects of resveratrol on NMDA-induced cell death and calcium influx in immature and mature rat primary cortical neurons were determined and compared. Moreover, the potencies and efficacies of resveratrol to inhibit NR1/NR2A, NR1/NR2B, NR1/NR2C, and NR1/NR2D NMDAR expressed in HEK 293 cells were evaluated. Results: Resveratrol significantly attenuated NMDA-induced cell death in mature neurons, but not in immature neurons. Resveratrol also concentration-dependently reduced NMDA-induced calcium influx among all NMDAR subtypes, but displayed NR2 subunit selectivity, with a potency rank order of NR2B = NR2D > NR2A = NR2C and an efficacy rank order of NR2B = NR2C > NR2A = NR2D. Data show the stronger inhibitory effects of resveratrol on NR1/NR2B than other subtypes. Moreover, resveratrol did not affect hippocampal long-term potentiation (LTP), but impaired long-term depression (LTD). Discussion: These findings reveal the specific NMDAR modulating profile of resveratrol, providing further insight into potential mechanisms underlying the protective effects of resveratrol on neurological disorders.
    關聯: Nutritional Neuroscience, Vol.24, No.6, pp.443-458
    数据类型: article
    DOI 連結: https://doi.org/10.1080/1028415X.2019.1641995
    DOI: 10.1080/1028415X.2019.1641995
    显示于类别:[神經科學研究所] 期刊論文

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