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Title:	Serotonin receptor HTR6 mediates dietary restriction-induced memory enhancement
Authors:	廖瑞銘 Liao, Ruey-Ming Teng, Ling-Ling Lu, Guan-Ling Chiou, Lih-Chu Lin, Wei-Sheng
Contributors:	心理系
Date:	2019-04
Issue Date:	2019-11-21 10:40:57 (UTC+8)
Abstract:	Dietary restriction (DR; sometimes called calorie restriction) has profound beneficial effects on physiological, psychological, and behavioral outcomes in animals and in humans. We have explored the molecular mechanism of DR-induced memory enhancement and demonstrate that dietary tryptophan—a precursor amino acid for serotonin biosynthesis in the brain—and serotonin receptor 5-hydroxytryptamine receptor 6 (HTR6) are crucial in mediating this process. We show that HTR6 inactivation diminishes DR-induced neurological alterations, including reduced dendritic complexity, increased spine density, and enhanced longterm potentiation (LTP) in hippocampal neurons. Moreover, we find that HTR6-mediated mechanistic target of rapamycin complex 1 (mTORC1) signaling is involved in DR-induced memory improvement. Our results suggest that the HTR6-mediated mTORC1 pathway may function as a nutrient sensor in hippocampal neurons to couple memory performance to dietary intake.
Relation:	PLOS Biology, Vol.17, No.3, pp.e2007097
Data Type:	article
DOI link:	https://doi.org/10.1371/journal.pbio.2007097
DOI:	10.1371/journal.pbio.2007097
Appears in Collections:	[Department of Psychology] Periodical Articles

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