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    题名: Serotonin receptor HTR6 mediates dietary restriction-induced memory enhancement
    作者: 廖瑞銘
    Liao, Ruey-Ming
    Teng, Ling-Ling
    Lu, Guan-Ling
    Chiou, Lih-Chu
    Lin, Wei-Sheng
    贡献者: 心理系
    日期: 2019-04
    上传时间: 2019-11-21 10:40:57 (UTC+8)
    摘要: Dietary restriction (DR; sometimes called calorie restriction) has profound beneficial effects on physiological, psychological, and behavioral outcomes in animals and in humans. We have explored the molecular mechanism of DR-induced memory enhancement and demonstrate that dietary tryptophan—a precursor amino acid for serotonin biosynthesis in the brain—and serotonin receptor 5-hydroxytryptamine receptor 6 (HTR6) are crucial in mediating this process. We show that HTR6 inactivation diminishes DR-induced neurological alterations, including reduced dendritic complexity, increased spine density, and enhanced longterm potentiation (LTP) in hippocampal neurons. Moreover, we find that HTR6-mediated mechanistic target of rapamycin complex 1 (mTORC1) signaling is involved in DR-induced memory improvement. Our results suggest that the HTR6-mediated mTORC1 pathway may function as a nutrient sensor in hippocampal neurons to couple memory performance to dietary intake.
    關聯: PLOS Biology, Vol.17, No.3, pp.e2007097
    数据类型: article
    DOI 連結: https://doi.org/10.1371/journal.pbio.2007097
    DOI: 10.1371/journal.pbio.2007097
    显示于类别:[心理學系] 期刊論文

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