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    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/55286

    Title: 多角度驗證軀體標記假說之建構、生理反應關連性以及神經處理機制 (I)
    Other Titles: Examining the Construct, Physiological, and Neural Correlates of Somatic Marker Hypothesis with Multiple Approaches
    Authors: 顏乃欣;廖瑞銘;鄭中平
    Contributors: 國立政治大學心理學系
    Keywords: 情緒;決策判斷;軀體標記假說;腹側中央前額葉;事件關連電位
    emotion;decision making;somatic marker hypothesis;VMPFC;ERP
    Date: 2007
    Issue Date: 2012-11-08 14:04:44 (UTC+8)
    Abstract: 此三年的研究計劃中,欲探討軀體標記假說(Somatic Marker Hypothesis;SMH)尚未解決的問題,包括(1)在愛荷華賭局作業(Iowa gambling task;IGT)中包含了混淆變項;(2)Damasio 用來測量軀體標記的方法(即:膚電反應)不夠敏感;(3)由腦傷患者或生理測量所獲得的實驗結果,無法有效釐清現象間的因果關係。因此,這項計畫中設計了人類與動物行為實驗,並使用認知模型方法(cognitive modeling method)來檢驗IGT 的建構,探討與決策行為相關的生理現象,以及與IGT 作業中各成份產生交互作用的大腦機制。在人類行為實驗中,將綜合多項生理指標(如:膚電反應、心跳頻率測量、臉部肌電反應、腦電位反應以及事件關連電位等)來測量生理反應與IGT 成分的共變。在動物行為實驗中,將使用腦區破壞與藥物注射等神經藥理學的技術來探索軀體標記假說的神經基礎。此外,認知模型被用來估計決策歷程中的各個成分。預計三年研究期內將進行六項研究。第一年的研究將著重於探討生理測量方法的相關議題,以及處理軀體標記訊號的機制腦側化的問題;第二年的研究將著重於釐清IGT 作業中各成份造成的混淆;第三年的研究則主要在檢驗與軀體標記假說相關的中樞神經系統,包含ERP 成分與大腦相關區域。
    此兩年的研究計劃中,欲探討軀體標記假說(Somatic Marker Hypothesis;SMH)尚未解決的問題,包括(1)在愛荷華賭局作業(Iowa gambling task;IGT)中包含了混淆變項;(2)Damasio用來測量軀體標記的方法(即:膚電反應)不夠敏感;(3)由腦傷患者或生理測量所獲得的實驗結果,無法有效釐清現象間的因果關係。因此,這項計畫中設計了人類與動物行為實驗,並使用認知模型方法(cognitive modeling method)來檢驗IGT的建構,探討與決策行為相關的生理現象,以及IGT作業中各變項所產生的作用。在人類行為實驗中,將綜合多項生理指標(如:膚電反應、心跳頻率測量等)來探討生理反應與IGT牌局的作用結果。在動物行為實驗中,將探究老鼠風險選擇的行為。此外,認知模型被用來估計決策歷程中的各個成分。在過去一年裡,我們進行了三個主要的研究:在研究ㄧ中,我們成功地複製了愛荷華賭局作業,並藉由作業的結果調整了認知模式的參數。在研究二中,研究的結果並不支持軀體標記假說,參與者在選高風險或壞牌前,其SCR的反應是較高的。而在研究三中,我們用老鼠進行了動物風險行為的探討,並企圖建立動物的風險行為模式。
    A two year integrative project is proposed to investigate some unsolved issues inSomatic Marker Hypothesis (SMH): 1) the Iowa Gambling Task (IGT) consists variouscomponents which may complicate the interpretations driven from it, 2) the measurementthat Damasio used to index somatic marker (i.e. SCR) is not sensitive to capture theprocesses of decision making, and 3) studies with patients or physiological measurement arelimited in extracting causal relationship. In this project, both human and animal studies, aswell as cognitive modeling method, were processed to examine the construct of IGT, toexplore the physiological correlates of decision making. In human studies, a variety of physiological measurements (e.g. SCR, heart rate) were incorporated to probe the consequences of the deck and the variance of reward and punishment. In animal study, an animal model of risky choice behavior had developed by the use of the rat. Furthermore, cognitive modeling were applied to estimate components of decision processes. Three studies are proposed within this year. In Study One, we successfully replicated the original IGT task, and we found that parameters of expectancy-valence model are not scale free. In Study Two, our results did not support somatic maker hypothesis. Participants made more risky and bad choices even when the anticipatory SCR associated with them were higher. In Study Three, an animal model of risky choice behavior has been recently developed in this laboratory by the use of the rat. These animal data indicated the probabilistic-based risky choice behavior could be developed in the laboratory animal.
    Relation: 基礎研究
    研究期間:9608~ 9707
    Data Type: report
    Appears in Collections:[心理學系] 國科會研究計畫

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