政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/65230

English | 正體中文 | 简体中文 | Post-Print筆數 : 27 | Items with full text/Total items : 109953/140903 (78%)
Visitors : 46055872 Online Users : 985

RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.

Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer

政大機構典藏 > 理學院 > 神經科學研究所 > 期刊論文 > Item 140.119/65230

Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/65230

Title:	Metabotropic glutamate receptor 5 modulates behavioral and hypothermic responses to toluene in rats
Authors:	Chan, Ming-Huan;Lee, Chia-Chi;Lin, Bih-Fen;Wu, Chia-Yen;Chen, Hwei-Hsien 詹銘煥
Contributors:	神科所
Keywords:	Toluene;mGluR5;NMDA receptor;Motor coordination;Learning;Hypothermia
Date:	2012.12
Issue Date:	2014-04-09 17:17:42 (UTC+8)
Abstract:	Toluene, a widely used and commonly abused organic solvent, produces various behavioral disturbances in both humans and animals. Blockade of N-methyl-d-aspartate (NMDA) receptors has been suggested to play a critical role in acute toluene-induced behavioral manifestations. Activation of type 5 metabotropic glutamate receptors (mGluR5) attenuates behavioral responses induced by NMDA receptor blockade. The present study elucidated the role of mGluR5 on toluene-induced behavioral and hypothermic responses. Male Sprague–Dawley rats received the mGluR5 agonist (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) or antagonist 6-methyl-2-[phenylethynyl]-pyridine (MPEP) prior to toluene administration. Rotarod test, step-down inhibitory avoidance learning task, and rectal temperature were monitored. Pretreatment of CHPG and MPEP attenuated and potentiated these toluene-induced responses, respectively. In addition, the inhibitory effects of CHPG on toluene-induced motor incoordination, learning impairment, and hypothermia were reversed by the protein kinase C (PKC) inhibitor chelerythrine chloride. These findings suggest that mGluR5 may modulate the neural circuits responsible for motor incoordination, learning impairment, and hypothermic action of toluene through a PKC-dependent signal transduction pathway.
Relation:	Pharmacology, biochemistry and behavior,103(2), 418-424
Source URI:	http://dx.doi.org/10.1016/j.pbb.2012.09.019
Data Type:	article
Appears in Collections:	[神經科學研究所 ] 期刊論文

Files in This Item:

File	Description	Size	Format
418-424.pdf		342Kb	Adobe PDF2	1071	View/Open

社群 sharing

著作權政策宣告 Copyright Announcement

1.本網站之數位內容為國立政治大學所收錄之機構典藏，無償提供學術研究與公眾教育等公益性使用，惟仍請適度，合理使用本網站之內容，以尊重著作權人之權益。商業上之利用，則請先取得著作權人之授權。
The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.

2.本網站之製作，已盡力防止侵害著作權人之權益，如仍發現本網站之數位內容有侵害著作權人權益情事者，請權利人通知本網站維護人員(nccur@nccu.edu.tw)，維護人員將立即採取移除該數位著作等補救措施。
NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.

Loading...